Adriana Muhlia

Name: Adriana

Surname: Muhlia

Email: amuhlia@ciad.mx

Position: Principal Researcher. Bioenergetics and Molecular Genetics Lab.

Institution: Centro de Investigación en Alimentación y Desarrollo, A.C.

Address:  km 0.6 Carretera a Ejido La Victoria

Research Projects:


– The Mitochondrial function of Crustaceans:  genes, proteins and their regulatory mechanisms.

– The digestive enzymes of crustaceans: novel enzymes with dual roles.

Possible collaboration interests:


– Tolerance to hypoxia from marine invertebrates

– The effect of environmental stress in the mitochondrial functions

– The study of crustacean enzymes

Publications in the last ten years:


– Sánchez-Paz, A., García-Carreño, F., Hernández-López, J., Muhlia-Almazán, A., and Yepiz-Plascencia, G. 2007. Effect of short-term starvation on hepatopancreas and plasma energy reserves of the Pacific white shrimp Litopenaeus vannamei. Journal of Experimental Marine Biology and Ecology. 340 (184-193).

-Gómez-Anduro, G.A., Sotelo-Mundo, R.R., Muhlia-Almazán, A. and Yepiz Plascencia, G. 2007. Tissue-specific expression and molecular modeling of cytosolic manganese superoxide dismutases from the white shrimp Litopenaeus vannamei. Developmental and Comparative Immunology. 31: 783- 789.

– Clavero-Salas, A., Sotelo-Mundo, R., Gollas-Galván, T.,Hernández-López, J.,  Peregrino-Uriarte, A., Muhlia-Almazán, A., and Gloria Yepiz-Plascencia. 2007. Transcriptome analysis of gills from the white shrimp Litopenaeus vannamei infected with White Spot Syndrome Virus. Fish and Shellfish Immunology. 23: 459- 472.

– Muhlia-Almazán, A., Sánchez-Paz, A., García-Carreño, F.L. 2008. Invertebrate trypsins: a review. Journal of Comparative Physiology. Part B. 178: 655-672.

-Aispuro-Hernandez, E., Garcia- Orozco, K.D, Muhlia-Almazan, A. del-Toro-Sanchez, L., Robles-Sanchez, R.,  Hernandez, J,  Gonzalez-Aguilar, G., Yepiz-Plascencia, G., Sotelo-Mundo, R.R. 2008. Shrimp thioredoxin is a potent antioxidant protein. Comparative Biochemistry and Physiology. Part C. 148: 94-99.

-Muhlia-Almazan, A.*, Martinez-Cruz,O.  Navarrete del Toro, M. A., Garcia-Carreño, F.L., Arreola,R., Sotelo-Mundo,R.  and  Yepiz-Plascencia, G. 2008. Nuclear and mitochondrial subunits from the white shrimp Litopenaeus vannamei FoF1 ATP-synthase complex: cDNA sequence, molecular modeling, and mRNA quantification of atp9 and atp6. Journal of Bioenergetics and Biomembranes. 40:359-369.

-Sánchez-Paz A., Soñanez-Organis J. G., Peregrino-Uriarte A.B., Muhlia-Almazán A., and Gloria Yepiz-Plascencia. 2008. Response of the phosphofructokinase and pyruvate kinase genes expressed in the midgut gland of the Pacific white shrimp Litopenaeus vannamei during short-term starvation. Journal of Experimental Marine Biology and Ecology. 362: 79-89.

-Peregrino-Uriarte, A.B.,Varela-Romero, A., Muhlia-Almazán, A., Anduro-Corona, A. Vega-Heredia, S., Gutiérrez-Millán, L.E.,De la Rosa-Vélez, J.,Yepiz-Plascencia, G. 2009. The complete mitochondrial genomes of the yellowleg shrimp Farfantepenaeus californiensis and the blue shrimp Litopenaeus stylirostris (Crustacea: Decapoda). Comparative Biochemistry and Physiology, Part D 4: 45–53.

-Mercier, L., Racotta, I.S., Yepiz-Plascencia, Muhlia-Almazán, A., Civera, R., Quiñones, M., Wille, M., Sorgeloos, P., Palacios, E. 2009. Effect of diets containing different levels of highly unsaturated fatty acids on physiological and immune responses in Pacific whiteleg shrimp Litopenaeus vannamei (Boone) exposed to handling stress. Aquaculture Research. 40: 1849-1863.

-Rojo, L., Muhlia-Almazan, A.,  Saborowski, R., and García-Carreño F. 2010. Aspartic  Cathepsin D endopeptidase contributes to extracelular digestión in clawed lobsters Homarus americanus and Homarus gammarus. Marine Biotechnology. 12(6): 696-707.

-de-la-Re-Vega, E., Garcia-Orozco, K., Arvizu- Flores, A., Yepiz-Plascencia, G., Muhlia-Almazan, A.,Hernández, J., Brieba, L.G., and Sotelo-Mundo, R. 2011. White spot syndrome virus Orf514 encodes a bona fide DNA polymerase. Molecules. 16(1): 532-542.

-Martínez-Cruz, O., García-Carreño, F.L., Robles-Romo, A., Varela-Romero, A., Muhlia-Almazan, A. 2011. Catalytic subunits atpα and atpβ from the Pacific white shrimp Litopenaeus vannamei FOF1 ATP-synthase complex: cDNA sequences, phylogenies, and mRNA quantification during hypoxia. Journal of Bioenergetics and Biomembranes. 43:119-133.

-de-la-Re-Vega, E., Muhlia-Almazan, A., Arvizu- Flores, A., Islas-Osuna, M.A., Yepiz-Plascencia, G., Brieba, L.G., and Sotelo-Mundo, R. 2011. Molecular modeling and expression of the Litopenaeus vannamei proliferating cell nuclear antigen (PCNA) after white spot syndrome virus infection. Results in Immunology. 1: 24-30.

-Stephens, A., Rojo, L., Araujo-Bernal, S., Garcia-Carreño, F. and Muhlia-Almazan, A. 2012. Cathepsin B from the shite shrimp Litopenaeus vannamei: cDNA sequence analysis, tissue-specific expression and its biological activity. Comparative Biochemistry and Physiology. PartB. 161:32-40.

-Sánchez-Paz, A. Sotelo-Mundo, R. and Muhlia-Almazán, A. 2012.The Challenges of Developing a Treatment that fully Protects Shrimp against WSSV Infection: a perspective. In: Advances in Zoology Research. (Ed). Jenkins, O.P. Vol. 1. NOVA Science Publishers. Pp. 1-30. ISBN: 978-1-61470-960-2.

-Martinez-Cruz, O.; Sanchez-Paz, J.A., Garcia-Carreño, F.L., Jimenez-Gutierrez, L.R., Navarrete del Toro, M.A. and Muhlia-Almazan, A. 2012. Invertebrates Mitochondrial Function and Energetic Challenges. In: 218ISBN 978-953-51-0090-4,  pp. 181-218.

-Peregrino-Uriarte, A., Muhlia-Almazan, A., Arvizu-Flores, A., Gomez-Anduro, G., Gollas-Galvan, T., Yepiz-Plascencia, G. and Sotelo-Mundo, R. 2012. Shrimp invertebrate lysozyme i-lyz: Gene structure, molecular model and response of c and i lysozymes to lipopolysaccharide (LPS). Fish & Shellfish Immunology. 32: 230-236.

-Rocha, J., Garcia-Carreño, F.,  Muhlia-Almazán, A., Peregrino-Uriarte, A., Yepiz-Plascencia, G., Córdova-Murueta, J. 2012. Cuticular chitin synthase and chitinase mRNA of whiteleg shrimp Litopenaeus vannamei during the molting cycle. Aquaculture. 330: 111-115.

-Garcia-Orozco, K., Sanchez-Paz, A., Aispuro-Hernandez, E., Gomez-Jimenez, S., Lopez-Zavala, A., Araujo-Bernal, S. and Muhlia-Almazán, A. 2012. Gene expression and protein levels of thioredoxin in the gills from the whiteleg shrimp Litopenaeus vannamei infected with two different virus: the WSSV or IHHNV. Fish and Shellfish Immunology. 32(6): 1141-1147.

-Martinez-Cruz, O., Calderon de la Barca, A.M., Uribe-Carbajal, S. and Muhlia-Almazán, A. 2012. The function of mitochondrial FoF1 ATP-synthase from the whiteleg shrimp Litopenaeus vannamei during hypoxia. Comparative Biochemistry and Physiology, part B. 162(4): 107-112.

-Jimenez-Ruiz, E., Ocaño-Higuera, V., Maeda-Martınez, A.,Varela- Romero, A., Marquez-Rıos, E., Muhlia-Almazán, A., Castillo-Yañez, F.J. 2013. Effect of Seasonality and Storage Temperature on rigor mortis in the Adductor Muscle of Lion-paw Scallop Nodipecten subnodosus. Aquaculture. 388-391: 35-41.

-Jimenez-Gutierrez, L.R., Hernandez-Lopez, J., Islas-Osuna, M.A., Muhlia-Almazán, A. 2013. Three nucleus-encoded subunits of mitochondrial cytochrome c oxidase of the whiteleg shrimp Litopenaeus vannamei: cDNA characterization, phylogeny and mRNA expression during hypoxia and reoxygenation. Comparative Biochemistry and Physiology, part B. 166(1): 30-39.

-Palafox-Carlos, H., Contreras-Vergara. C.A., Muhlia-Almazán, A., Islas-Osuna, M.A., Gonzalez-Aguilar, G.A. 2014. Expression and enzymatic activity of phenylalanine amonio-lyase and p-coumarate 3-hydroxylase in mango (Mangifera indica var. Ataulfo) during ripening. Genetics and Molecular Research. 13(2):3850-3858.

-Jimenez-Gutierrez, L.R, Uribe-Carvajal, S., Sanchez-Paz, A., Chimeo, C., and Muhlia-Almazán, A. 2014. The cytochrome c oxidase and its mitochondrial function in the whiteleg shrimp Litopenaeus vannamei during hypoxia. Journal of Bioenergetics and Biomembranes. 46(3): 189-196.

-García-Carreño F.L., Navarrete del Toro M.A., Muhlia-Almazán A. 2014. The role of Lysosomal cysteine proteases in crustaceans immune response. Invertebrate Survival Journal. 11: 109-118.

-Sanchez-Paz, A., Muhlia-Almazan, A., Saborowski R, García-Carreño F, Mendoza-Cano F. 2014. Marine viruses: the beneficial side of a threat. Applied Biochemistry and Biotechnology. 174: 2368-2379.

-Martinez-Cruz, O., Arvizu-Flores, A., Sotelo-Mundo, R., Muhlia-Almazán, A. 2015.The nuclear encoded subunits gamma, delta and epsilon from the shrimp mitochondrial F1-ATP synthase, and their transcriptional response during hypoxia. Journal of Bioenergetics and Biomembranes. 47: 225-234.

-Stephens-Camacho N.A., Muhlia-Almazán A., Sánchez-Paz J.A., Rosas-Rodríguez JA. 2015. Surviving environmental stress: The role of betaine aldehyde dehydrogenase in marine crustaceans. Invertebrate Survival Journal. 12: 66-74.

-Delgado-Gaytan, M.F., Hernández-Palomares, M.L.E., Soñanez-Organis J.G., Muhlia-Almazán A, Sánchez-Paz J.A., Stephens-Camacho, N.A., Valenzuela-Soto, E., Rosas-Rodriguez, J.A. 2015. Molecular characterization and organ-specific expression of the gene that encodes betaine aldehyde dehydrogenase from the white shrimp Litopenaeus vannamei in response to osmotic stress. Comparative Biochemistry and Physiology. 189B: 40-46.

-Chimeo ,C., Fernandez-Gimenez A.V., Campanella M., Mendez-Romero, O., Muhlia-Almazán, A. 2015. The shrimp mitocondrial FoF1 ATPase inhibitory factor 1 (IF1). Journal of Bioenergetics and Biomembranes. 47(5):383-393.

-Rosas Lemus M., Uribe-Alvarez C., Contreras-Zentella M., Luévano Martinez L., Chiquete-Félix N, Morales-Garcia N., Espinosa-Simon, E., Muhlia-Almazan A., Escamilla E, Uribe-Carvajal S. 2016. Oxygen: from toxic waste to optimal (toxic) fuel of life. In: Free Radicals and Diseases. Eds. INTECH. Chapter 1: 1-19 pp.